Document Type: Primary Research paper
The collected alkaloid compounds of Gelliodes carnosa sponge species from depth of 5-6 meters of Nay band Bay (Iran’s coasts of Persian Gulf) were extracted by three different methods The obtained extract was tested on two gram-positive bacteria (Staphylococcus aureus, PTCC 1189, Bacillus subtilis, PTCC 1156), and five gram-negative bacteria (Escherichia coli,PTCC 1763, Pseudomonas saeroginosa, PTCC 1310, Proteus mirabilis, PTCC 1076, Serattia marcescens, Klebsiella pneumonia), and six pathogenic fungi (Candida albicans, PTCC 5027, Fusarium solani, PTCC 5248, Aspergillus niger, PTCC 5223, Saprolegnia sp., Fusarium sp.1, Fusarium sp.2). The extracted alkaloid compounds from the three methods had a significant inhibitory activity on the growth of all the bacteria and fungi. The anti-bacterial properties of these compounds were more than their anti-fungal properties. The most anti-bacterial and antifungal properties were from the extracts derived by the second method where it created a halos of above 25mm against all the fungi and bacteria. The lowest activity was from the extracts obtained by the third method against Klebsiella pneumonia, Aspergillus niger, and Fusarium sp.2 where an average of 9mm halos was created. Based on the obtained results this sponge can be considered as a source of bioactive substances which have inhibitory activities against some pathogens.