CALCIUM SIGNAL MODULATION FOR CANCER CELL APOPTOSIS – A SIDDHA NANOTHERAPEUTIC APPROACH

Document Type : Primary Research paper

Authors

1 CRRI, Velumailu Siddha Medical College and hospital, Sriperumbuthur

2 MITBCC-Full membership of British council of complementary therapies in Siddha

3 Lecturer, Velumailu Siddha Medical College and hospital, Sriperumbuthur

4 Principal, Velumailu Siddha Medical College and hospital, Sriperumbuthur

Abstract

In recent days, Siddha system of medicine has emerged as an arena for researches especially in the management of cancer. Nearly 14.5 lakhs estimated number of people are being reported to be affected with cancer in India every year. Researches on cancer biology have concluded that alteration in calcium channel pump is a main characteristic feature of cancers and Calcium has ability to regulate both cell death and proliferation. To eliminate cancer cell from the human body is one of the most important challenges for immune system. Thus, the therapy that have the ability to modulate calcium signaling in the cancer cells to regulate proliferation and apoptosis can be beneficial to have target action on cancer cells. The drug with Calcium helps to prevent, suppress or reverse the process of carcinogenesis before development of malignancy. This article deals with intervention of Calcium in promoting cancer cell apoptosis and validation of Calcium rich siddha therapy such as Man kombu parpam, Anda vodu parpam, Nandu odu parpam, Aamai odu parpam, Sangu parpam, Anda chunnam which has anticancer activity. This review critically explores the novelty behind the traditional use of siddha medicine for the effective management of cancer.

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