Document Type : Primary Research paper
College of Education for Girls - Tikrit University- Chemistry Department
The research aims to study the evaluation of the level of the thyroid peroxidase enzyme and some of the enzyme antioxidants (catalase CAT, glutathione peroxidase GPX, superoxide dismutase SOD) among thalassemia patients in Salah Al-Din Governorate. The research included (90) samples, (45) samples with Thalassemia and (45) healthy sample and described them as the control group. Their ages ranged between (9-30) years, and the results showed a decrease in the studied biochemical indicators. A significant decrease was found as the activity of the thyroid peroxidase enzyme (TPO) was recorded in Thalassemia patients, (58.4 ± 3.7) compared with the healthy group (261.7 ± 24.7). Also, there was a significant decrease in the activity of SOD enzyme in Thalassemia patients (278.1 ± 32.8 *) compared with the healthy group (329.6 ± 58.6). No significant difference was found in the activity of the glutathione peroxidase enzyme GPX in thalassemia patients (20.0 ± 7.0) compared with the healthy group (20.7 ± 7.7). Also, there was no significant difference in the activity of catalase enzyme CAT in thalassemia patients (168.9 ± 25) compared with the healthy group (166.4 ± 26.7). The statistical results showed a negative correlation between the thyroid peroxidase enzyme and (glutathione peroxidase, superoxide dismutase) and a positive correlation between the thyroid peroxidase enzyme and catalase with varying correlation coefficient values.