Pre-Clinical Studies Of The Preparation "Cobafen" Lyophilizate For Preparation Of Solution For Injection With Solvent

Non-steroidal anti-inflammatory drugs (NSAIDs), which have more than 50 years of history, are the most demanded drugs in the modern world. With the general trend towards aging of human society, the number of patients requiring the use of NSAIDs is also growing [1]. The class of traditional NSAIDs currently includes more than 20 drugs that are similar in chemical structure, but differ from each other in the strength of the analgesic effect and the frequency of side effects. In accordance with WHO recommendations, pain should be assessed when prescribing pain medications. It is well known that NSAIDs are an effective pathogenetic therapy for acute or chronic pain, which is used by millions of patients around the world. According to WHO statistics, this figure is almost 30 million people, among them 40% are elderly people, and this figure is constantly growing [2]. Mecobalamin (a derivative of vitamin B12) is necessary for cell growth and reproduction, for the formation of deoxyribose and DNA, creatine, methionine - a donor of methyl groups, in the synthesis of a lipotropic factor - choline, for the conversion of methylmalonic acid into succinic acid, which is part of myelin, for the utilization of propionic acid ... S-adenosylmethionine from homocysteine due to the transfer of methyl and other one-carbon fragments.
Diclofenac sodium is an NSAID derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).
Inhibits the synthesis of proteoglycan in cartilage. In rheumatic diseases, it reduces joint pain at rest and during movement, as well as morning stiffness and swelling of the joints, and helps to increase the range of motion. Reduces post-traumatic and postoperative pain and inflammatory edema.1
Suppresses platelet aggregation. With prolonged use, it has a desensitizing effect.
The drug has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of cyclooxygenase - the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.2 The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits the synthesis of proteoglycan in cartilage. In rheumatic diseases, it reduces joint pain at rest and during movement, as well as morning stiffness and swelling of the joints, and helps to increase the range of motion. Reduces post-traumatic and postoperative pain and inflammatory edema. Suppresses platelet aggregation induced by adenosine diphosphate and collagen.